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KMID : 0191120010160030313
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Journal of Korean Medical Science
2001 Volume.16 No. 3 p.313 ~ p.316
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Effect of Thyroid Hormone on the Alcohol Dehydrogenase Activities in Rat Tissues
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Dong-Sun Kim
Chang-Beom Lee/Yong-Soo Park/You-Hern Ahn/Tae-Wha Kim/Choon-Suhk Kee/Ju-Seop Kang/Ae-Son Om
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Abstract
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The effects of thyroid hormone on hepatic and gastric alcohol dehydrogenase (ADH) activities
(nM of NADH/min/mg of cytosolic protein) have been investigated in male Sprague Dawley rats
treated with thyroxine (1 mg/kg, po) for 14 days. Whereas hepatic ADH activity in thyroxine-treated
rats decreased by 61.3% of control rats (26.4 vs 43.2, p<0.001), gastric ADH activity increased
by 262.9% of control rats (4.9 vs 1.9, p<0.001). As for the activities of the lung and kidney,
thyroxine treatment did not produce any statistically significant changes. These data suggest
that thyrotoxicosis causes a decrease of hepatic alcohol metabolism, and that the increase of
gastric ADH activity in thyrotoxic rats can partly restore the first-pass metabolism of ethanol.
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